PROMETHEUS® Monitr™ Crohn's Disease Test

The serum test that gives the mucosa a voice

Measure and monitor mucosal healing status at any time in your Crohn's disease patients with 1 noninvasive test

Measure and monitor mucosal healing status at any time in your Crohn's disease patients with 1 noninvasive test

Mucosal healing provides an objective measure of therapeutic response in Crohn's disease management.1 However, current assessment methods may not provide needed information, particularly when assessing disease activity in difficult-to-reach locations like the small bowel.1-3

The PROMETHEUS® Monitr™ Crohn's Disease Test evaluates multiple mucosal damage and repair processes, regardless of disease location.1 It features a proprietary algorithm specific to mucosal healing—and a unique combination of 13 biomarkers—to provide information that cannot be obtained with endoscopy or biopsy.

Comprehensive assessment

Monitr™ provides a comprehensive Crohn's disease patient assessment with or without endoscopy.

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Quantitative test results

Every Monitr test report provides a single objective Mucosal Healing Index Score* that is consistent with severity of disease.

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Proven test performance4,5

Monitr has a 90% concordance rate with endoscopically visualized mucosal inflammation.5

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References



*In a study where 748 serum samples from 396 adult Crohn's disease patients were divided into 2 cohorts: 335 samples from 278 patients were used to develop the Mucosal Healing Index (biomarker expression was modeled against endoscopic scoring CDEIS [Crohn’s Disease Endoscopic Index of Severity] or SES-CD [Simple Endoscopic Score for Crohn’s Disease]) and 412 samples from 118 adult Crohn's disease patients were analyzed with endoscopic scoring for independent validation.4

References:
  1. 1.De Cruz P, Kamm MA, Prideaux L, Allen PB, Moore G. Mucosal healing in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2013;19(2):429-444.

  2. 2.Shah SC, Colombel JF, Sands BE, Narula N. Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn's disease. Aliment Pharmacol Ther. 2016;43(3):317-333.

  3. 3.Bryant RV, Winer S, Travis SP, Riddell RH. Systematic review: histological remission in inflammatory bowel disease. Is ‘complete' remission the new treatment paradigm? An IOIBD initiative. J Crohns Colitis. 2014;8(12):1582-1597.

  4. 4.Vermeire S, D'Haens G, Hale M, et al. A novel serum test to describe the mucosal healing state by disease location in Crohn's disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.

  5. 5.Kelly OB, Silverberg MS, Dulai PD, et al. Development and validation of a multi-marker serum test for the assessment of mucosal healing in Crohn's disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.